If you eat two devil fruits, you may experience some strange and unpredictable effects. Some people have reported feeling intense guilt or being compelled to do things they ordinarily wouldn’t. There are also reports of people gaining extraordinary strength or size and knowledge beyond what is normally possible. It’s important to remember that these effects are largely anecdotal, and there is no guarantee that eating two devil fruits will have any negative consequences.
Eating two Devil Fruits can have serious consequences in the One Piece manga and anime. After Luffy ate the Gum-Gum Fruit and the Bara Bara Fruit, he was able to stretch his body like rubber. However, if he were to eat a second Devil Fruit, his body would become incredibly heavy, and he would be unable to move. This is because the Devil Fruits cancel out each other’s powers. Sanji found this out the hard way after he ate the Para Para Fruit and the Doku Doku Fruit. The Doku Doku fruit turned his blood into poison, and he was unable to move or fight for a period of time.